• When studying the potential of HATi for

  2021-09-06

  

  When studying the potential of HATi for the treatment of inflammatory lung diseases, investigating lung tissue specific effects may be particularly relevant since local administration of small molecule inhibitors in lung tissue is possible and is already applied for inhaled glucocorticoids in the tr

• br Acknowledgements This work was supported by NIH HL

  2021-09-06

  

  Acknowledgements This work was supported by NIH HL111674 (JHF), and the Antoinette E. (“Mimi”) & Herman Boehm Foundation (JK). The authors wish to acknowledge the valuable assistance of the Functional Genomics Core of the University of Colorado, Denver. Introduction The 21-gene recurrence sco

• Here we examined Meckel s cartilage of mice where Setdb

  2021-09-06

  

  Here, we examined Meckel's cartilage of mice where Setdb1 was knocked out only in neural crest derived inhibitor of apoptosis proteins with the purpose of investigating the roles of Setdb1 in Meckel's cartilage, a supportive tissue for mandible formation. We observed enlarged Meckel's cartilage tha

• br Conflict of interest statement br Acknowledgments The

  2021-09-06

  

  Conflict of interest statement Acknowledgments The authors would like to thank Dr. Linda Console-Bram for her editing of this review, Valentina Lucchesi for help with the figures, and acknowledge funding from NIH/NIDA (DA023204). GPR35 is an orphan G protein-coupled receptor (GPCR) implicat

• In conclusion GPR inhibits and GPR enhances the cell motile

  2021-09-06

  

  In conclusion, GPR120 inhibits and GPR40 enhances the cell motile activity stimulated by TPA in melanoma cells, while MMP-9 activation was reduced by GPR40. In contrast, GPR40 negatively regulated cellular functions of fibrosarcoma Hydroxysafflor yellow A australia [11]. Taken together, it is sugge

• Recently a receptor for nicotinic acid named

  2021-09-06

  

  Recently, a receptor for nicotinic acid, named GPR109A (also known as HM74a in man or PUMA-G in the mouse) has been identified (Lorenzen et al., 2001, Lorenzen et al., 2002, Soga et al., 2003, Tunaru et al., 2003, Wise et al., 2003). This receptor, a member of the 7 transmembrane G-protein coupled f

• L-Cysteinesulfinic acid In conclusion we demonstrated that t

  2021-09-03

  

  In conclusion, we demonstrated that the atypical high-basal activity of the mGlu3 L-Cysteinesulfinic acid results mostly from its activation by low ambient glutamate concentrations. This is due to a unique interaction network located in the extracellular domain of the mGlu3 receptor. This network a

• br Introduction The glucagon receptor GCGR is

  2021-09-03

  

  Introduction The glucagon receptor (GCGR) is a G-protein-coupled receptor expressed mainly in the liver and kidney. Upon glucagon binding, it activates the stimulatory G protein (Gs) and increases cAMP level, subsequently transducing glucagon signaling involved in glucose, amino acids and lipid m

• br Conclusion In the present study we found

  2021-09-03

  

  Conclusion In the present study, we found that the majority of commercially available antibodies and antibody-based tools against galanin and its receptors that we tested do not meet validation requirements. Therefore, critical validation of these tools by the user is essential before being used

• Albumin is the major carrier of free fatty

  2021-09-03

  

  Albumin is the major carrier of free fatty acids (FFAs) in plasma [59], and harbours seven binding sites that are common to FFAs with a range of chain-lengths (C10-C18) across its three domains (Fig. 1a) [60,61]. In vitro, saturated, mono- and poly-unsaturated FFAs, with chain lengths ranging from C

• Formyl peptide receptors FPRs are a family of surface expres

  2021-09-03

  

  Formyl peptide receptors (FPRs) are a family of surface-expressed, G protein-coupled receptors [7]. The three members, FPR1, FPR2 and FPR3, share significant sequence homology, but have different functional properties [7]. While FPRs are mainly expressed by innate leukocytes, they are also found on

• Previously we have isolated liver FBPase from

  2021-09-03

  

  Previously we have isolated liver FBPase from Pelophylax esculentus (former Rana esculenta, Frost et al., 2006) and characterized its kinetic properties (Dziewulska-Szwajkowska and Dzugaj, 1999) on the contrary the muscle FBPase has never been fully characterized. The primary aim of the present pape

• Next we aimed to investigate if the cardiac apoptosis induce

  2021-09-03

  

  Next, we aimed to investigate if the cardiac apoptosis induced by CO-HFD, LA, T1DM or hyperglycemia involves up-regulation and activation of Fas/FasL-mediated cell death and if such effects are mediated by ROS and/or Ca+2/calcineurin/NFAT signaling axis. Similar to previous reports, [8], [9], [10],

• LDC1267 br Methods br Results We have previously used

  2021-09-03

  

  Methods Results We have previously used ß-hex assays in HeLa LDC1267 to study the role of lysosomal exocytosis on transition metal clearance and the effects of transition metals on lysosomal exocytosis [26], [29], [40]. ß-hex is a lysosomal enzyme, the delivery of which to the extracellular me

• br Discussion The aim of

  2021-09-03

  

  Discussion The aim of the present study was to extend the list of ASIC ligands and to check if histamine receptors ligands can also affect ASICs. The novel finding is that not only histamine but also thioperamide, 1-metylhistamine and Nα-methylhistamine are active ASIC1a potentiators, while other

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